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Feds Award $3 Million In Grants To Study Marijuana Ingredients As Alternatives To Opioids

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The federal government has awarded $3 million in grants for research into the therapeutic benefits of ingredients in marijuana other than THC, emphasizing their potential as alternatives to prescription opioids.

In a notice published on Thursday, the National Institutes of Health (NIH) explained why the studies were necessary and listed grant recipients and the subjects they will investigate. That includes research into the use of CBD for arthritis pain, which will be led by New York University School of Medicine.

“The treatment of chronic pain has relied heavily on opioids, despite their potential for addiction and overdose and the fact that they often don’t work well when used on a long-term basis,” Helene Langevin, director of the National Center for Complementary and Integrative Health (NCCIH), said in a press release. “There’s an urgent need for more effective and safer options.”

A total of nine grants were issued, with NIH stating that the funds will help identify alternative treatment options for pain and provide information about the impact of consuming cannabis compounds such as CBD and other lesser-known cannabinoids as well as terpenes found in the plant.

“The cannabis plant contains more than 110 cannabinoids and 120 terpenes, but the only compound that’s been studied extensively is THC,” the press release said.

But while THC is known to treat certain forms of pain, NIH is concerned that its intoxicating effects limit its medical applicability.

“THC may help relieve pain, but its value as an analgesic is limited by its psychoactive effects and abuse potential,” David Shurtleff, deputy director of NCCIH, said. “These new projects will investigate substances from cannabis that don’t have THC’s disadvantages, looking at their basic biological activity and their potential mechanisms of action as pain relievers.”

NIH first announced that it would be issuing grants for studies into minor cannabinoids and terpenes last year.

Federal health agencies aren’t the only institutions interested in learning about marijuana compounds other than THC. On Wednesday, a Senate committee issued a spending report that called for research into CBD and CBG while also criticizing the federal drug scheduling system for inhibiting such research.

Read descriptions of the federal cannabinoid and terpene research grant awards below:

Mechanism and Optimization of CBD-Mediated Analgesic Effects; Boston Children’s Hospital, Boston,; Zhigang He, Ph.D., B.M., and Juan Hong Wang, Ph.D. This project will investigate how the pain-relieving effects of cannabidiol (CBD) and other minor cannabinoids may be modulated by the activity of potassium-chloride cotransporter 2 (KCC2), a chloride extruder expressed in most neurons. (Grant 1R01AT010779)

Neuroimmune Mechanisms of Minor Cannabinoids in Inflammatory and Neuropathic Pain; University of California, San Francisco; Judith Hellman, M.D., and Mark A. Schumacher, M.D., Ph.D. This project will explore the effects of minor cannabinoids on inflammatory and neuropathic pain in vitro and in vivo, focusing on the interactions of the cannabinoids with the peripheral receptor called TRPV1 and a cannabinoid receptor, CB1R. (Grant 1R01AT010757)

Minor Cannabinoids and Terpenes: Preclinical Evaluation as Analgesics; Research Triangle Institute, Research Triangle Park, North Carolina; Jenny L. Wiley, Ph.D. This project will evaluate purified biosynthesized minor cannabinoids and selected terpenes alone and in planned combinations to determine their potential efficacy as pain relievers against acute thermal, inflammatory, neuropathic, and visceral pain. (Grant 1R01AT010773)

Identifying the Mechanisms of Action for CBD on Chronic Arthritis Pain; New York University School of Medicine, New York City; Yu-Shin Ding, Ph.D. This project will use neuroimaging studies and behavioral assessments to investigate the mechanisms of action of CBD in the modulation of chronic pain associated with osteoarthritis in a mouse model. (Grant 1R21AT010771)

Synthetic Biology for the Chemogenetic Manipulation of Pain Pathways; University of Texas, Austin; Andrew Ellington, Ph.D. This project will use a novel method to evolve individual variants of cannabinoid receptor type 2 (CB2) that interact with high affinity with minor cannabinoids and evaluate the new variants in a mouse model of pain. (Grant 1R21AT010777)

Exploring the Mechanisms Underlying the Analgesic Effect of Cannabidiol Using Proton Magnetic Resonance Spectroscopy; University of Utah, Salt Lake City; Deborah A. Yurgelun-Todd, Ph.D. This project will use proton magnetic resonance spectroscopy (1H-MRS) to evaluate changes in brain chemistry in critical pain-processing regions after short-term administration of a cannabis extract enriched in CBD. (Grant 1R21AT010736)

Mechanistic Studies of Analgesic Effects of Terpene Enriched Extracts from Hops; Emory University, Atlanta; Cassandra L. Quave, Ph.D. This project will take a multidisciplinary approach to investigate the analgesic effects of terpenes from Humulus lupulus (hops), a plant that is closely related to cannabis and has a very similar terpene profile. (Grant 1R21AT010774)

Systematic Investigation of Rare Cannabinoids With Pain Receptors; University of Illinois at Urbana-Champaign; David Sarlah, Ph.D. This project involves synthesizing several classes of rare phytocannabinoids, systematically evaluating their anti-inflammatory potential, and examining the effects of the compounds with the strongest anti-inflammatory potential on the major receptors involved in pain sensation. (Grant 1R21AT010761)

Analgesic efficacy of single and combined minor cannabinoids and terpenes; Temple University, Philadelphia; Sara J. Ward, Ph.D. This project will use rodent models of pain to evaluate the effects of four biologically active components of cannabis that may act synergistically to protect against pain development and to assess the interactions of these four substances with morphine. (Grant 1R01AT010778)

Senate Report Slams Drug Scheduling System For Blocking Marijuana Research

 

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Kyle Jaeger is Marijuana Moment's Los Angeles-based associate editor. His work has also appeared in High Times, VICE and attn.

Politics

Anniversary Of Alcohol Prohibition’s End Is A Good Time To Legalize Marijuana, Presidential Candidate Castro Says

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Former Housing and Urban Development (HUD) Secretary Julián Castro marked the 86th anniversary of the repeal of alcohol prohibition in the U.S. on Thursday by calling for the legalization of marijuana.

The 2020 Democratic presidential candidate tweeted about Repeal Day, a commemoration of the ratification of the 21st Amendment, which ended federal prohibition of booze.

“86 years later, it’s time we end the federal prohibition of Cannabis once and for all,” he said. “Legalize it. Regulate it. Expunge the records of the victims of the war on drugs.”

Castro, who included proposals to legalize marijuana and expunge prior cannabis convictions in a criminal justice reform plan he released in October, isn’t the only one calling attention to the ongoing prohibition of the plant on Repeal Day. Several other Twitter users, including a congressional candidate, have made similar points.

While Castro hasn’t been quite as vocal about marijuana reform in his campaign as some of the other candidates, he has recently expressed openness to even broader drug policy initiatives such as decriminalizing possession of all drugs.

During a forum hosted by the Iowa Harm Reduction Coalition last month, Castro said “I do think though that it’s worth taking a look at that and understanding where are those opportunities, either to decriminalize or at least deemphasize enforcement so that we’re not penalizing individuals who should instead be getting the treatment that they need.”

He also said he supports communities establishing safe injection sites where individuals can consume illicit drugs under medical supervision to reduce the risk of overdose deaths and help people get into treatment.

South Bend, Indiana Mayor Pete Buttigieg and Rep. Tulsi Gabbard (D-HI), rival presidential candidates, are in favor of drug decriminalization, and Sens. Elizabeth Warren (D-MA) and Bernie Sanders (I-VT) back safe consumption facilities. Entrepreneur Andrew Yang says he would decriminalize opioids and invest federal resources into opening safe injection sites across the country.

Cory Booker’s Marijuana Agenda Highlighted In Three Super PAC Ads

Photo courtesy of YouTube/IHRC.

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Business

Hemp Businesses Need Clarity On Credit Card Processing, GOP Congressman Tells Federal Regulators

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One day after federal financial regulators issued guidance relaxing requirements for banks doing business with hemp companies, Rep. Andy Barr (R-KY) called for further input on how financial institutions can work with the industry—particularly when it comes to credit card processing.

“I have heard from Kentucky bankers about this. They welcome this guidance, and it will go a long way to help the hemp industry thrive,” Barr said on Wednesday at a House Financial Services Committee hearing.

But after thanking witnesses—including Federal Deposit Insurance Commission (FDIC) Chairwoman Jelena McWilliams and National Credit Union Association (NCUA) Chairman Rodney Hood—he reminded them that there is still much work to be done to give hemp businesses fair access to financial services.

Specifically, Barr called credit card processing services for Kentucky hemp companies “unreliable” and “unavailable” while pointing out that Tuesday’s hemp banking memo failed to clearly address the problem.

“I’ve read the guidance closely, as you can tell, and I didn’t see that in there,” Barr said. “That’s the financial service that has really been unreliable and spotty, so if you need to update that guidance to give more clarity to card processing businesses, that might be in order.”

McWilliams replied that her agency would “certainly take a look” at the issue and offered that “to the extent that we need to do additional explaining, we are more than happy to engage in that process.”

In response, Barr reminded her of the broader goals of congressional action to legalize hemp products under the 2018 Farm Bill.

“Congressional intent is not only that the regulators confirm the legality of industrial hemp and hemp related retailers under the Farm bill, but that those retailers and merchants can use card processing services to sell the product itself,” he said.

Watch Barr press federal regulators on hemp business credit card processing below:

This isn’t the first time Barr has raised the issued of hemp businesses’ ability to accept payments with cards.

“I’ve had constituent businesses tell me that their access to financial products, specifically card services, have actually deteriorated since we descheduled industrial hemp in the Farm Bill,” he said at an earlier hearing in May. “This obviously conflicts with congressional intent.”

The congressman’s questions and comments at the most recent hearing are emblematic of a larger bipartisan push to provide updated regulations to the hemp industry and banks that work with it.

Most notably, the House overwhelmingly approved the Secure and Fair Enforcement (SAFE) Banking Act in September. The legislation would protect banks and credit unions from being penalized by federal regulators for working with marijuana businesses, and Barr added an amendment clarifying that the protections also apply to hemp companies.

However, the vote came later than some observers expected, which may help explain why the growth in the number of financial institutions working with cannabis companies seems to have slowed down in the prior quarter of the fiscal year.

NCUA’s Hood, whose agency’s earlier hemp guidance released in August was among the first federal clarifications on the issue after the Farm Bill became law, testified on Wednesday about the steps NCUA is taking to open up access to financial services for companies in the industry.

“We are continuing to work with the industry to provide training to our examiners,” Hood said. “We will now be working with the [U.S. Department of Agriculture] and other related parties to ensure that we get it right. We will be hosting a series of roundtables to gain insights from entities around best practices.”

In submitted testimony, he wrote that NCUA expects “to continue updating the credit union community now that the USDA has published its interim final rule [for hemp]” and said the agency has “received interest from credit unions eager to know the rules of the road for serving hemp-related businesses in their communities, and we want to make sure those credit unions have what they need to make informed decisions in this area.”

Jospeh Otting, comptroller of the currency, also discussed the latest guidance from federal regulators in testimony he submitted to the panel, writing that the joint statement from federal regulators “provides clarity regarding the legal status of commercial growth and production of hemp and relevant requirements for banks.”

Also discussed at the hearing was NCUA’s recent regulatory action on employment at credit unions by people with criminal records. Initially proposed by the agency in July, the move to allow participation by people convicted of minor offenses like simple drug possession was officially enacted by this week.

Asked by Rep. Brad Sherman (D-CA) “what are you doing, and what can Congress do” to assist in the advancement of the so-called “second chance” decision, Hood responded that NCUA “recognized that individuals who have committed nonviolent criminal offenses who have paid their debts to society should have opportunities to work in federal credit unions.”

McWilliams called the second chance decision an “important social justice issue” and said FDIC is currently seeking input on how best to move forward. “I personally believe we can go a long way to enabling those individuals to re-enter the workforce,” she said.

Watch lawmakers and regulators discuss financial services employment by people with prior convictions below:

Outside of the House Financial Services panel, several lawmakers on Capitol Hill have recently pushed to make business easier for hemp companies.

Last week, for example, Senate Minority Leader Chuck Schumer (D-NY) called on USDA to extend its public comment period for proposed hemp regulations. And in October, Sens. Ron Wyden (D-OR) and Jeff Merkley (D-OR) sent a letter to USDA asking for five specific changes in the rules.

Federal Regulators Ease Hemp Banking Protocols Following Crop’s Legalization

Photo courtesy of Pixabay.

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Politics

Cory Booker’s Marijuana Agenda Highlighted In Three Super PAC Ads

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A super PAC working to get Sen. Cory Booker (D-NJ) elected president is putting a lot of emphasis on the candidate’s marijuana reform agenda, releasing multiple new advertisements highlighting his position on the issue.

United We Win, an organization that’s not formally associated with Booker’s presidential campaign but supports his candidacy, included cannabis reform in three separate spots over the past month. Two of those ads contrasted the senator’s stance with that of former Vice President Joe Biden, a rival contender for the Democratic nomination who opposes adult-use legalization.

“Joe Biden is wrong about weed,” one ad, released on Tuesday, states. “He called marijuana a ‘gateway drug,’ but science says he’s wrong. Cory Booker knows that legalizing marijuana is the sensible, humane thing to do.”

Another, posted last week, shows a clip of Booker at the most recent Democratic debate, where Booker called out Biden over the gateway drug comment that quickly became a source of controversy ahead of the event. Booker said at the time that he was shocked to hear Biden say he doesn’t support legalization because he thinks cannabis could lead to the use of more dangerous drugs.

About one week after the former vice president made the remarks, he reversed his stance and said evidence doesn’t support the gateway drug theory. This wasn’t the first time that the senator has blasted Biden over his cannabis record, as Booker said in July that his opponent’s drug reform plan was inadequate.

“Joe Biden had more than 40 years to get this right,” Booker said. “The proud architect of a failed system is not the right person to fix it.”

The other ad, released last weekend, pits Booker against South Bend, Indiana Mayor Pete Buttigieg, who is also competing for the Democratic nomination. United We Win included Booker’s plan to legalize marijuana in a list of policy proposals that they said make him a more fit candidate and also noted his role in advancing criminal justice reform legislation in a Republican-controlled Senate.

Buttigieg does support legalization, so the point of bringing that position up didn’t appear to be an attempt to contrast each candidate’s platform on that issue in particular.

The super PAC’s website also prominently spotlights Booker’s marijuana record, including the issue as one of six main menu links across its top banner—alongside “criminal justice,” “gun safety” and “defeating Trump.”

There’s also an article recapping the senator’s debate attack on Biden’s anti-legalization comments.

Booker has certainly taken pains to emphasize his advocacy for cannabis reform during the campaign, and he’s the sponsor of comprehensive legislation that would not only federally deschedule marijuana but also penalize states that continue to dole out cannabis enforcement in a discriminatory manner.

While United We Win isn’t affiliated with Booker’s team, and federal law prohibits the PAC and the campaign from coordinating with one another, the strong focus on his marijuana platform reflects a growing recognition that, especially among Democratic voters, legalization is an important issue that candidates and political operatives are seeking to leverage during this election.

Cory Booker’s Mom Scolds Him For Marijuana Joke At Joe Biden’s Expense

Photo courtesy of YouTube/United We Win.

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