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Colorado Legalization Didn’t Increase Teen Marijuana Use, Another Study Finds

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The latest in a string of studies to show that marijuana legalization does not lead to increased underage cannabis consumption has just been released.

“Our results suggest that adolescents’ marijuana use may not increase immediately following initiation of retail marijuana sales, which seems plausible given that they cannot legally access marijuana from the retail market,” concludes the study of Colorado teens, published in the journal Prevention Research last week.

“Overall, we did not find a significant change in the prevalence of adolescent marijuana use from shortly before to after the implementation of a recreational marijuana law in Colorado.”

Researchers from the University of Colorado, New York University, Johns Hopkins University and the Colorado Department of Public Health and Environment teamed up to compare data from youth drug use surveys from fall 2013, which was just prior to the start of legal marijuana sales, and fall 2015.

Frequency Of Use And Consumption At School Decrease

In addition to “an absence of significant effects for change in lifetime or past 30-day marijuana use,” the results also showed that teens reporting that they had used cannabis during the past month did so less frequently and that use on school properties declined.

“Among those reporting past 30-day marijuana use, there was a significant decline in frequent use (i.e., > 20 occasions of use in the past 30 days) and use on school property.”

Another significant change the study identified between the two time periods was a decline in perceived harm associated with cannabis use, but that was not accompanied with an increase in perceived ease of access to marijuana or any changes in perceived wrongfulness or perceived parental disapproval.

The findings bolster the position of legalization advocates, who have long argued that ending prohibition for adults and allowing them to buy marijuana in regulated stores that check the ages of their customers will not cause more young people to use cannabis.

“We did not find a significant effect associated with the introduction of legal sales of recreational marijuana to adults in Colorado on adolescent (illegal) use.”

Marijuana possession and home cultivation became legal in Colorado shortly after voters approved a legalization ballot measure in late 2012, prior to the first dataset in the study. Legal retail sales began on January 1, 2014.

The findings of the new research were consistent across demographic subgroups.

The researchers looked at “change in current marijuana use from 2013 to 2015 by school characteristic including school poverty, proportion of student enrollment that was Black or Hispanic, urbanicity of the school, and local policy regarding retail marijuana sales in 2015.”

“We did not find a statistically significant change in current marijuana use for any of these school characteristics.”

The study authors hypothesized that the decline in frequent cannabis use and use on school property is related to societal changes ushered in as part of legalization:

“It is not clear what accounts for this finding, but we suspect it may be related to the public discourse around marijuana policy leading up to and following the passage and enactment of…Colorado’s [legalization law] in 2012. Media coverage, school-based prevention programs, and public health and advocacy campaigns focused strongly on the potential negative impacts on youth during this time, and there was widespread agreement that the legal market should be inaccessible to adolescents… Therefore, it is possible that those adolescents who use marijuana had more received more attention from friends, parents, or school personnel and may have opted to use off-school grounds or less frequently. This interpretation may be further supported by the finding of an increase in perceived wrongness reported among current marijuana users.”

The findings add to a growing body of research showing that legalization is not associated with increased teen marijuana use.

A federal survey released late last year, for example, showed that rates of marijuana use among 8th, 10th and 12th graders is lower now that it was prior when to states began enacting legalization in 2012.

Another study looked at state-by-state youth use rates and found that state medical cannabis laws did not lead to increases.

The new study was supported with federal funding through the National Institutes of Health.

Legalizing Marijuana Doesn’t Lead To Higher Youth Use, New Study Shows

Photo courtesy of Carlos Gracia.

Marijuana Moment is made possible with support from readers. If you rely on our cannabis advocacy journalism to stay informed, please consider a monthly Patreon pledge.

Tom Angell is the editor of Marijuana Moment. A 15-year veteran in the cannabis law reform movement, he covers the policy and politics of marijuana. Separately, he founded the nonprofit Marijuana Majority. Previously he reported for Marijuana.com and MassRoots, and handled media relations and campaigns for Law Enforcement Against Prohibition and Students for Sensible Drug Policy. (Organization citations are for identification only and do not constitute an endorsement or partnership.)

Politics

Federal Health Agency Releases List Of Marijuana Research Priorities

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In one of the latest signs that the federal government is recognizing the reality of the marijuana legalization movement’s continued success, a top health agency released an extensive list of cannabis-related research objectives it hopes to fund.

The notice, published on Wednesday, notes the rapid evolution of marijuana policies in the U.S. and globally, which is “far outpacing the knowledge needed to determine and minimize the public health impacts of these changes.”

“A growing number of states have loosened restrictions on cannabis, including those on sales and use, by passing medical marijuana laws or by making cannabis legal for adult recreational use, and in some cases, states have done both,” the National Institute on Drug Abuse (NIDA) wrote.

It also referenced a 2018 report from a cannabis policy working group that was tasked with identifying “cannabis policy research areas with the greatest urgency and potential for impact.”

Evidently, there are quite a few areas that fit that description, as NIDA listed 13 research objectives of “programmatic interest.” And while the agency has previously called for studies into several areas that are featured on the notice, there are others that signal NIDA is evolving in its understanding of research needs as more states opt to legalize.

For example, NIDA is not simply focusing on providing grants to explore the health risks of cannabis use, it’s also interested in learning about “reasons for initiation and continued use of marijuana for therapeutic purposes” as well as investigating “how cannabis industry practices, including research on marketing, taxes, and prices, impact use and health outcomes.”

The agency also wants to fund studies that look at the differences in legal marijuana regulatory schemes in various jurisdictions to “understand which combinations or components minimize harm to public health.”

Other research goals NIDA described include exploring the impact of cannabis use during pregnancy and developing roadside testing instruments to identify THC impaired drivers as well as standards to measure marijuana dosing.

Here’s the full list of research objectives: 

—Develop standards for measuring cannabis (including hemp and hemp product) dose, intoxication, and impairment.

—Enhance existing epidemiology research to study trends for cannabis use and CUD; including new products, patterns of use, and reasons for use in different populations.

—Characterize the composition/potency of cannabis, methods of administration, cannabis extracts/concentrates, and cannabis of varying constituents (e.g. cannabinoid or terpene content), as well as how those factors impact physical and mental health.

—Determine the physical and mental health antecedents of use, as well as outcomes of use.

—Explore the impact of polysubstance use on health outcomes, including interactions (substitution/complementation) with alcohol, tobacco, and prescription and nonprescription opioids.

—Examine reasons for initiation and continued use of marijuana for therapeutic purposes.

—Investigate the effects of different patterns of cannabis use on brain development, educational attainment, and transition to work and adult roles.

—Identify the effects of maternal cannabis consumption during pregnancy and breastfeeding.

—Develop effective roadside tests for cannabis impairment that can be practically deployed by law enforcement.

—Determine the prevalence of cannabis-involved vehicular crashes and other types of injury or property damage.

—Investigate how cannabis industry practices, including research on marketing, taxes, and prices, impact use and health outcomes (e.g. how different price points impact consumption patterns across different levels of use).

—Determine the impact of federal, state, and local marijuana policies and their implementation on use and health outcomes.

—Explore the heterogeneity of regulatory schemes (e.g. models for retail distribution of cannabis) to understand which combinations or components minimize harm to public health.

A number of federal health agencies have issued several notices for marijuana-related research opportunities in recent months. One that received particular attention came from NIDA in May, when it said applications were open for what is essentially a professional research-grade marijuana joint roller and analyst position.

While NIDA said that research isn’t keeping up with the rapid reform movement, its director also acknowledged in April that the federal drug scheduling system—which regards cannabis as a tightly restricted Schedule I drug—has inhibited such research by making it difficult for scientists to access marijuana.

Women Lawmakers From Across U.S. Hold Marijuana Conference And Tour Dispensary

Photo by Aphiwat chuangchoem.

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Study Reviews How Marijuana Compounds Inhibit Tumor Growth And Kill Cancer Cells

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A recent scientific review concludes that marijuana’s legal status should be revisited given existing research that shows cannabis’s components can inhibit tumor growth and help with cancer management.

Researchers at Amity University in India detailed the scientific literature surrounding the effects of cannabinoids on different cancer types and also looked at marijuana’s anti-nausea, appetite stimulation and pain relieving qualities.

Besides treating symptoms of chemotherapy side effects, cannabis also shows potential in slowing the growth of cancer cells and even kill cancer cells in certain cases, the researchers wrote.

“THC and CBD exhibit effective analgesic, anxiolytic, and appetite-stimulating effect on patients suffering from cancer.”

But that’s not all. “Apart from exerting palliative effects, THC also shows promising role in the treatment of cancer growth, neurodegenerative diseases (multiple sclerosis and Alzheimer’s disease), and alcohol addiction and hence should be exploited for potential benefits,” an abstract of the study, published in the Journal of Cancer Research and Therapeutics, states.

The majority of the studies that were reviewed were based on in vitro experiments, meaning they did not involve human subjects but rather isolated cancer cells from humans, while some of the research used mice.

Cannabinoids appear to “exert potent [anti-growth] activity and activate various apoptotic mechanisms eventually leading to cell death” of cancer cells associated with glioma, an aggressive form of brain cancer.

At least once clinical trial showed that patients with recurrent glioblastoma multiforme who were treated with a “proprietary combination of THC and CBD” in addition to a traditional pharmaceutical had a higher one-year survival rate (83 percent) compared to a placebo group (53 percent).

Another study found blood cancer cells that were treated with two synthetic endocannabinoids activated receptors that “mediated apoptosis,” or the death of the cells.

In certain cell lines of prostate cancer, similar findings were observed. There was “[s]ignificant cell growth inhibition followed by apoptosis” in one particular cancer cell type in a “study which was designed to evaluate the in vitro effects of endocannabinioids such as 2-arachidonoyl glycerol, anadamine, and its synthetic analog methazolamide.”

Less research has been conducted on the effects of cannabis on lung, breast, oral and liver cancers, but the study authors documented instances where mice with certain lung cancer types treated with THC experienced a “notable reduction of the subcutaneous tumor growth and lung metastasis” of those cells, “prompting its significance as a novel therapeutic molecule in lung cancer treatment.”

But while THC is a common study focus, other cannabinoids show particular potential in treating different cancer types, they found. For example, a synthetic CBD compound (940-CBD) was the most effective “in terms of antiproliferative effects and invasiveness” of a particular breast cancer cell line.

When treated with THC, an oral cancer cell line that’s “highly resistant to anticancer drugs,” showed increased “cellular respiration inhibition,” whereas another conventional treatment option “showed no such effect.”

While researchers have investigated a wide range of cancer treatments, “the utilization of THC and their derivatives is still unexplored pharmacologically owing to their ‘habit-forming’ nature,” the researchers concluded. “Specific targeting of cannabinoid receptors can be used to manage severe side effects during chemotherapy, palliative care and overall cancer management.”

“Furthermore, research evidences on cannabinoids have suggested tumor inhibiting and suppressing properties which warrant reconsidering legality of the substance,” they said. “Studies on [cannabinoid] receptors, in case of cancers, have demonstrated the psychoactive constituents of cannabinoids to be potent against tumor growth.”

Because the activation of CB1 and CBD2 cannabinoid receptors “tends to limit human cancer cell growth,” there may be a “role of the endocannabinoid system as a novel target for treatment of cancers” and “[f]urther explorations are required to exploit cannabinoids for an effective cancer management.”

The findings reflect another recent study that also explored the therapeutic potential of cannabis extracts in the treatment of different cancers. Like this new review, it demonstrated that while variation in cannabinoids that are used to treat distinct cancer cell lines is an important consideration, the growing data on marijuana’s ability to inhibit cell growth and kill cancer cells indicates that it should be a major area of research going forward.

Psychedelics Can Help Patients With Depression And Anxiety, Study Finds

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Science & Health

Marijuana Legalization Causes ‘Significant Decline’ In Opioid Overdoses, New Research Finds

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Two new studies find that opioid-related deaths decline when states legalize access to marijuana. In fact, when adult-use cannabis laws are in place, the rate of opioid overdoses declines by at least 20 percent.

Both papers, published in the journal Economic Inquiry, not only show the impact of passing such laws, but also how dispensaries play a role in helping to quell these deaths.

The first study, helmed by researchers in Massachusetts and Colorado, claims to be the first to show the causal effects of access to recreational cannabis on opioid mortality.

“We find that marijuana legalization causes a significant decline in opioid mortality— especially deaths from synthetic opioids—with particularly pronounced benefits in states that have legalized recreational usage,” the study’s authors write. “Yet it is not legalization, per se, that produces these gains; rather, states that have legal access via dispensaries see the largest reductions in mortality.”

“We estimate that [recreational marijuana laws] reduce annual opioid mortality in the range of 20%–35%, with particularly pronounced effects for synthetic opioids.”

The study used three main sources of data: death rates involving all opiates, prescription opioids and synthetic opioids from January 1999 through the end of 2017; the history of marijuana legalization in each state (including when legislation was passed and when dispensaries opened for business) and state-level demographic information. During the study period, 29 states had approved medical cannabis, while recreational marijuana was legalized in eight states plus the District of Columbia. According to the Centers for Disease Control and Prevention, the number of opioid-related deaths has increased six times over between 1999 and 2017. Additionally, 36 percent of the 47,600 opioid overdoes in 2017 involved prescription opioids.

After running several statistical and mathematical models that included checks to ensure their results were consistent, the study’s authors found that broader adult-use laws reduce a state’s opioid death rate between 20 percent (for all opiates and prescription opioids) to 35 percent (for synthetic opioids).

“Recreational marijuana laws affect a much larger population than medical marijuana laws, yet we know relatively little about their effects,” study co-author Nathan W. Chan, PhD said in a press release. “Focusing on the recent wave of recreational marijuana laws in the U.S., we find that opioid mortality rates drop when recreational marijuana becomes widely available via dispensaries.”

“Our estimates are sizable,” the study itself states. “For reference, the average never-legalizer state has 4.82 fatalities per 100,000 people from All Opiates (Synthetic Opioids) annually, while for the average [medical marijuana law] state, these are 6.067 and 0.856 per 100,000 people. Thus, our estimates imply annual reductions in All Opioid mortality between 1.01 and 1.27 deaths per 100,000 people for non-[recreational marijuana law] states, on average. For a state with a population of 5 million (near the nationwide median), this would save on the order of 50 lives per year, or roughly 10 averted deaths from Synthetic Opioids alone.”

Those are conservative estimates, the authors add.

Additionally, models showed that white people and women saw the highest reductions in synthetic opioid deaths in states that legalized recreational cannabis: Whites experienced a 32 percent decrease, while the statistical effect for women was larger and “highly statistically significant” compared to what they found for men.

The authors did not identify what mechanism is responsible for this reduction in mortality rates, though past research suggests people who can legally access marijuana may substitute it for opioids. A recent study, for example, found the majority of people who shopped at cannabis retail shops reported using marijuana to help with pain and sleep.

The new study’s authors do stress, however, that the causal effect they identified is “highly robust.”

“Our bedrock findings remain unmoved by variations in modeling assumptions and selections of control variables, and our findings are further corroborated through placebo tests,” they write. “Our results show that there are substantial ancillary benefits to marijuana legalization, especially [recreational marijuana laws], and they offer important food for thought as many states continue to contemplate expansions to both medical and recreational marijuana access.”

Their findings support a growing body of research that has linked the availability of medical marijuana dispensaries with a drop in the rate of local opioid-related deaths.

In fact, that was the focus of the second cannabis-related study published recently in Economic Inquiry. According to its findings, after a medical cannabis dispensary opened in a county, prescription opioid deaths fell locally by approximately 11 percent. These results, the author writes, suggest “a substitutability between marijuana and opioids.”

“Furthermore,” the study concludes, “the unintended beneficial effects of allowing for marijuana dispensary operations should be considered by policymakers as they aim to curtail narcotic abuse and limit the impact of the opioid epidemic.”

New Analysis Explores Relationship Between Medical Marijuana And Opioid Overdoses

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