CBD, the widely available cannabinoid touted for various health benefits, may have the potential to help people with serious alcohol issues, according to a new review of current scientific evidence.
Not only does cannabidiol appear to “facilitate drinking reduction,” the paper’s authors write, but research also shows the compound “may provide idiosyncratic protection to the liver and brain, which could reduce the development and impact of alcohol-related liver disease and alcohol-related brain injury.”
The review, which is awaiting publication in the journal Frontiers in Pharmacology, offers a comprehensive look at how promising the data is so far regarding the effectiveness of CBD on alcohol use disorders (AUD). The authors, however, also call for human clinical trials, of which none have been published to date, to “pave the way for testing new harm reduction approaches in AUD.”
Researchers in France and Belgium reviewed 26 previous studies published between 1974 and June 2018 that explored the effects of CBD on animal subjects dosed with ethanol. They found several studies that showed CBD can reduce alcohol consumption. In one, for example, researchers discovered that mice administered CBD were less motivated to work (in this case, push a lever) for access to a liquid solution that included 8 percent of ethanol.
“Experimental studies converge to find that CBD reduces the overall level of alcohol drinking in animal models of AUD by reducing ethanol intake, motivation for ethanol, relapse, and by decreasing anxiety and impulsivity.”
Other studies found that mice regularly dosed with the non-intoxicating marijuana compound were also less likely to relapse after they’d been weaned off alcohol, even when they were stressed.
Because of its impact on various aspects of the disease (including “intake, motivation, relapse, anxiety and impulsivity”), CBD “could have a significant action on drinking levels in human subjects with AUD” the review’s authors write. They add, however, that it would be useful to have data using binge-drinking models and models that focus on long-term exposure to alcohol.
The review also highlighted evidence showing CBD could affect alcohol-related liver inflammation. In one study, researchers found that the livers of mice that’d been given the compound prior to being force-fed alcohol every 12 hours for five days were less damaged than those of mice not exposed to CBD.
“CBD seems to have valuable therapeutic properties for ethanol-induced liver damage, through multiple mechanisms,” including the reduction of oxidative stress, inflammation control, and the death of certain cells responsible for large amounts of scar tissue, the authors write.
Finally, CBD may also offer added protection to specific areas in the brain susceptible to alcohol-related damage. In one study, the brains of rats who’d binged on alcohol and given CBD were found to have lost “significantly” fewer brain cells in the hippocampus and entorhinal cortex. In those rats, CBD acted as a “neuroprotective antioxidant,” the review states. In another experiment, CBD also appeared to restore the neurological and cognitive functions of rats in acute liver failure.
“CBD has been found to reduce alcohol-related brain damage, preventing neuronal loss by its antioxidant and immunomodulatory properties.”
The authors suggest these overall benefits of CBD regarding problematic alcohol use may be due to the “complex” way the cannabinoid interacts with CB2 receptors, which are located throughout the body.
Currently, the review states, the pharmaceuticals available to help people with AUD stop drinking are “insufficiently effective at a population level, and new therapeutic prospects are needed. Moreover, no drug for reducing alcohol-related harms, either on the brain or the liver, has ever been studied.”
Plus, the authors conclude, “CBD could have many more positive effects in subjects with AUD, including antiepileptic, cardioprotective, anxiolytic, or analgesic ones. Human studies are thus crucially needed to explore the many prospects of CBD in AUD and related conditions.”
Meanwhile, there’s still time to submit public comments to the U.S. Food and Drug Administration on how the federal government should regulate CBD products, including supplements and foods. So far, hundreds of people have submitted information. The public comment period ends July 2.
Photo by Kimzy Nanney.
Federal Data Shows Youth Marijuana Use Isn’t Increasing Under Legalization
Despite prohibitionists’ often-expressed fears that legalization would lead more young people to use marijuana, new federal data released on Tuesday shows no such trend.
Reports of past-month cannabis use among those 12-17 remained stable from 2017 to 2018—and they’re significantly lower than in the years prior to when the first states began legalizing for adult use.
That’s according to the 2018 National Survey on Drug Use and Health (NSDUH), an annual report produced by the Substance Abuse and Mental Health Services Administration (SAMHSA).
“The percentage of adolescents in 2018 who used marijuana in the past year was lower than the percentages in 2002 to 2004 and in 2009 to 2013, but it was similar to the percentages in 2005 to 2008 and in 2014 to 2017,” SAMHSA said.
Recent studies that have used NSDUH data and other sources also demonstrate that youth marijuana use is not increasing post-legalization. In fact, research published in JAMA Pediatrics in July found that states with recreational cannabis experience a decline in underage marijuana use, with the study authors stating that regulated markets appear to deter illicit use.
Indeed, on a national scale, the percentage of adolescents who reported using marijuana began declining at a greater rate in the years after states started implementing legal cannabis systems. In 2018, 12.5 percent of those 12-17 said they used cannabis in the last month, compared to 13.5 percent in 2012, according to the NSDUH results.
Colorado and Washington State became the first U.S. states to vote to legalize marijuana for recreational use in late 2012, with legal sales commencing in 2014.
Between 2002 and 2018, the highest rate of adolescent marijuana use took place in 2002, when 15.8 percent reported past-month consumption.
“The survey results suggest that marijuana use among youth has remained stable and low in recent years, even as more states legalize medical and adult use,” Sheila Vakharia, PhD, deputy director of the Drug Policy Alliance’s Department of Research and Academic Engagement, told Marijuana Moment. “Rather than encouraging increased use, it is possible that legalization has limited access and deterred youth use. We find that these results strengthen the case for legalization in the interest of public health and protecting our nation’s young people.”
What’s more, the report found that cases of cannabis use disorder declined again for the 12-17 group in 2018, marking the seventh year in a row that fewer young people seem to be misusing the substance.
Interestingly, these trends are developing even as people’s perceptions of the risks of casual marijuana consumption are dropping. That seems to contradict an argument from reform opponents who claimed that legalizing cannabis would normalize it in such a way that underage individuals would feel more emboldened to experiment with marijuana.
Overall, marijuana consumption increased across age groups by about one percentage point over the past year, the survey found, with the bulk of that rise being attributable to those over 26. Past-month cannabis use for that demographic increased from 12.2 percent in 2017 to 13.3 percent in 2018.
This story was updated to include comment from the Drug Policy Alliance.
Photo courtesy of Philip Steffan.
Federal Health Agency Releases List Of Marijuana Research Priorities
In one of the latest signs that the federal government is recognizing the reality of the marijuana legalization movement’s continued success, a top health agency released an extensive list of cannabis-related research objectives it hopes to fund.
The notice, published on Wednesday, notes the rapid evolution of marijuana policies in the U.S. and globally, which is “far outpacing the knowledge needed to determine and minimize the public health impacts of these changes.”
“A growing number of states have loosened restrictions on cannabis, including those on sales and use, by passing medical marijuana laws or by making cannabis legal for adult recreational use, and in some cases, states have done both,” the National Institute on Drug Abuse (NIDA) wrote.
It also referenced a 2018 report from a cannabis policy working group that was tasked with identifying “cannabis policy research areas with the greatest urgency and potential for impact.”
Evidently, there are quite a few areas that fit that description, as NIDA listed 13 research objectives of “programmatic interest.” And while the agency has previously called for studies into several areas that are featured on the notice, there are others that signal NIDA is evolving in its understanding of research needs as more states opt to legalize.
For example, NIDA is not simply focusing on providing grants to explore the health risks of cannabis use, it’s also interested in learning about “reasons for initiation and continued use of marijuana for therapeutic purposes” as well as investigating “how cannabis industry practices, including research on marketing, taxes, and prices, impact use and health outcomes.”
Notice of Special Interest (NOSI): Public Health Research on Cannabis https://t.co/c04DIcmdAI
— NIH Funding (@NIHFunding) August 14, 2019
The agency also wants to fund studies that look at the differences in legal marijuana regulatory schemes in various jurisdictions to “understand which combinations or components minimize harm to public health.”
Other research goals NIDA described include exploring the impact of cannabis use during pregnancy and developing roadside testing instruments to identify THC impaired drivers as well as standards to measure marijuana dosing.
Here’s the full list of research objectives:
—Develop standards for measuring cannabis (including hemp and hemp product) dose, intoxication, and impairment.
—Enhance existing epidemiology research to study trends for cannabis use and CUD; including new products, patterns of use, and reasons for use in different populations.
—Characterize the composition/potency of cannabis, methods of administration, cannabis extracts/concentrates, and cannabis of varying constituents (e.g. cannabinoid or terpene content), as well as how those factors impact physical and mental health.
—Determine the physical and mental health antecedents of use, as well as outcomes of use.
—Explore the impact of polysubstance use on health outcomes, including interactions (substitution/complementation) with alcohol, tobacco, and prescription and nonprescription opioids.
—Examine reasons for initiation and continued use of marijuana for therapeutic purposes.
—Investigate the effects of different patterns of cannabis use on brain development, educational attainment, and transition to work and adult roles.
—Identify the effects of maternal cannabis consumption during pregnancy and breastfeeding.
—Develop effective roadside tests for cannabis impairment that can be practically deployed by law enforcement.
—Determine the prevalence of cannabis-involved vehicular crashes and other types of injury or property damage.
—Investigate how cannabis industry practices, including research on marketing, taxes, and prices, impact use and health outcomes (e.g. how different price points impact consumption patterns across different levels of use).
—Determine the impact of federal, state, and local marijuana policies and their implementation on use and health outcomes.
—Explore the heterogeneity of regulatory schemes (e.g. models for retail distribution of cannabis) to understand which combinations or components minimize harm to public health.
A number of federal health agencies have issued several notices for marijuana-related research opportunities in recent months. One that received particular attention came from NIDA in May, when it said applications were open for what is essentially a professional research-grade marijuana joint roller and analyst position.
While NIDA said that research isn’t keeping up with the rapid reform movement, its director also acknowledged in April that the federal drug scheduling system—which regards cannabis as a tightly restricted Schedule I drug—has inhibited such research by making it difficult for scientists to access marijuana.
Photo by Aphiwat chuangchoem.
Study Reviews How Marijuana Compounds Inhibit Tumor Growth And Kill Cancer Cells
A recent scientific review concludes that marijuana’s legal status should be revisited given existing research that shows cannabis’s components can inhibit tumor growth and help with cancer management.
Researchers at Amity University in India detailed the scientific literature surrounding the effects of cannabinoids on different cancer types and also looked at marijuana’s anti-nausea, appetite stimulation and pain relieving qualities.
Besides treating symptoms of chemotherapy side effects, cannabis also shows potential in slowing the growth of cancer cells and even kill cancer cells in certain cases, the researchers wrote.
“THC and CBD exhibit effective analgesic, anxiolytic, and appetite-stimulating effect on patients suffering from cancer.”
But that’s not all. “Apart from exerting palliative effects, THC also shows promising role in the treatment of cancer growth, neurodegenerative diseases (multiple sclerosis and Alzheimer’s disease), and alcohol addiction and hence should be exploited for potential benefits,” an abstract of the study, published in the Journal of Cancer Research and Therapeutics, states.
The majority of the studies that were reviewed were based on in vitro experiments, meaning they did not involve human subjects but rather isolated cancer cells from humans, while some of the research used mice.
Cannabinoids appear to “exert potent [anti-growth] activity and activate various apoptotic mechanisms eventually leading to cell death” of cancer cells associated with glioma, an aggressive form of brain cancer.
At least once clinical trial showed that patients with recurrent glioblastoma multiforme who were treated with a “proprietary combination of THC and CBD” in addition to a traditional pharmaceutical had a higher one-year survival rate (83 percent) compared to a placebo group (53 percent).
Another study found blood cancer cells that were treated with two synthetic endocannabinoids activated receptors that “mediated apoptosis,” or the death of the cells.
In certain cell lines of prostate cancer, similar findings were observed. There was “[s]ignificant cell growth inhibition followed by apoptosis” in one particular cancer cell type in a “study which was designed to evaluate the in vitro effects of endocannabinioids such as 2-arachidonoyl glycerol, anadamine, and its synthetic analog methazolamide.”
Less research has been conducted on the effects of cannabis on lung, breast, oral and liver cancers, but the study authors documented instances where mice with certain lung cancer types treated with THC experienced a “notable reduction of the subcutaneous tumor growth and lung metastasis” of those cells, “prompting its significance as a novel therapeutic molecule in lung cancer treatment.”
But while THC is a common study focus, other cannabinoids show particular potential in treating different cancer types, they found. For example, a synthetic CBD compound (940-CBD) was the most effective “in terms of antiproliferative effects and invasiveness” of a particular breast cancer cell line.
When treated with THC, an oral cancer cell line that’s “highly resistant to anticancer drugs,” showed increased “cellular respiration inhibition,” whereas another conventional treatment option “showed no such effect.”
While researchers have investigated a wide range of cancer treatments, “the utilization of THC and their derivatives is still unexplored pharmacologically owing to their ‘habit-forming’ nature,” the researchers concluded. “Specific targeting of cannabinoid receptors can be used to manage severe side effects during chemotherapy, palliative care and overall cancer management.”
“Furthermore, research evidences on cannabinoids have suggested tumor inhibiting and suppressing properties which warrant reconsidering legality of the substance,” they said. “Studies on [cannabinoid] receptors, in case of cancers, have demonstrated the psychoactive constituents of cannabinoids to be potent against tumor growth.”
Because the activation of CB1 and CBD2 cannabinoid receptors “tends to limit human cancer cell growth,” there may be a “role of the endocannabinoid system as a novel target for treatment of cancers” and “[f]urther explorations are required to exploit cannabinoids for an effective cancer management.”
The findings reflect another recent study that also explored the therapeutic potential of cannabis extracts in the treatment of different cancers. Like this new review, it demonstrated that while variation in cannabinoids that are used to treat distinct cancer cell lines is an important consideration, the growing data on marijuana’s ability to inhibit cell growth and kill cancer cells indicates that it should be a major area of research going forward.