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Three New Studies Explore Link Between Medical Marijuana Dispensaries And Youth Use

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Is there something going on in the City of Angels we don’t know about? Three separate new studies out this month investigate the association between the prevalence of medical marijuana dispensaries in Los Angeles County and marijuana use among teens and young adults. Their findings, however, are mixed.

As more states legalize marijuana use, local lawmakers have to decide whether they will allow dispensaries to open in their jurisdictions. A common argument from opponents is that the proximity to cannabis will negatively impact the communities in which these establishments reside. For example, many believe rates of crime and violence will rise, while supporters point out that cannabis businesses can fill otherwise-empty storefronts and usually have security guards and surveillance cameras on site that can deter crime at neighboring properties.

Another big concern for policymakers is whether high schoolers will be more likely to consume marijuana or use it more frequently because a dispensary is nearby or whether moving cannabis commerce into regulated establishments that ask for ID can actually dissuade youth consumption.

That’s what the new studies attempt to shed light on.

The first study, the dissertation of a doctoral student in the University of California Los Angeles School of Public Health, aimed to understand whether city ordinances that place restrictions on dispensaries or ban them altogether play a role in preventing high school students from consuming marijuana. Using a cross-sectional analysis with data from 57 L.A. County cities during the 2015-2016 and 2016-2017 school years, study author Catherine Branson found that cities that banned marijuana dispensaries did not have lower rates of marijuana use among students.

“Neither dispensary bans nor the number of dispensaries in a city (normalized by population to a rate of dispensaries per 10,000 city residents) were associated with student marijuana use in cross sectional analyses comparing the prevalence of student marijuana use across 57 cities in LA County,” she found.

Rather, Branson writes, having strict rules in place for licensure for these businesses, as well as where they’re located, offers the “most potent effects on student marijuana use.”

“In this study, students’ marijuana use was more strongly associated with the proximity of the nearest unlicensed dispensary to their school and the density of dispensaries within a several blocks from their school. These localized effects highlight the importance of enforcing city regulations that restrict dispensaries from operating near schools, whether those regulations are minimum distance requirements or policies that ban dispensaries altogether.”

She continued, “Furthermore, that localized effects were noted only for unlicensed outlets and not for licensed dispensaries indicates that enforcing existing ordinances by closing unlicensed outlets near schools could be an excellent first step for cities looking to prevent marijuana use among their students.”

Another study, this one published in the journal Addiction, focused on how the growing number of medical cannabis dispensaries in L.A. County is related to frequency of use for young adults living nearby. Researchers surveyed 1,887 people between the ages of 18-22 and asked them questions about marijuana consumption in the past month, including how many times they used per day. They also calculated the density of medical marijuana dispensaries around respondents’ homes.

According to the study‘s findings, 84 percent of participants reported living within four miles of at least 10 medical cannabis storefronts. As such, researchers found those who lived in a neighborhood with a higher concentration of dispensaries had consumed more marijuana in the past 30 days than those who did not. Interestingly, the study also pointed to storefront marijuana signage as a potential factor.

“For [medical marijuana dispensaries, or MMDs] with marijuana signage,” the authors write, “after adding [medical marijuana] card status, associations between density of MMDs with signage and positive expectancies and times used in a day remained statistically significant, and the magnitude of associations was four times as large for number of times used in a day, and five times as large for positive expectancies compared to total MMD count.”

Alternatively, a third recent study, published in Substance Use & Misuse, found that the density of medical dispensaries in L.A. did not actually affect current use among young people. The parameters they utilized, however, were different from the aforementioned work.

The authors interviewed 329 young adults ages 18-26 in 2014-2015. To determine frequency, researchers asked participants how many days they’d used marijuana in the past 90 days, as well as how many hits they typically did per day. They also identified more than 400 operational medical marijuana dispensaries within the city and calculated the density per population for each ZIP code area.

Their analysis found that the “density of medical marijuana dispensaries per square mile in Los Angeles ZIP code areas was not associated with” how often people—whether they were medical marijuana patients or not—toked in the past three months. These results support other studies that have found no relationship between proximity to medical marijuana establishments and use.

“Based upon these results,” the new study‘s authors speculate, “one could infer that the arrival of new marijuana dispensaries into neighborhoods and subsequent concentration of dispensaries in particular locations will not impact use of marijuana use among current marijuana users who live in areas with the greatest density of dispensaries—including those who cannot legally purchase marijuana from nearby dispensaries.”

Living Near Dispensaries Doesn’t Affect Teen Marijuana Use Or Attitudes, Study Finds

Photo by Sharon McCutcheon on Unsplash

Marijuana Moment is made possible with support from readers. If you rely on our cannabis advocacy journalism to stay informed, please consider a monthly Patreon pledge.

Kimberly Lawson is a former altweekly newspaper editor turned freelance writer based in Georgia. Her writing has been featured in the New York Times, O magazine, Broadly, Rewire.News, The Week and more.

Science & Health

Study Explores How Different Marijuana Extracts Kill Types Of Cancer Cells

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Marijuana extracts can impair the survival of certain types of cancer cells and inhibit their spread, according to a recent study. But the effects of those extracts vary significant based on their specific chemical makeup.

Researchers found that treating cancer cells with isolated ingredients in cannabis, such as THC alone, does not appear to be especially effective—but full cannabis extracts showed more promise. However, with the plant containing hundreds of compounds that appear in different concentrations across strains and preparations, researchers had their work cut out for them in investigating how various cannabinoid combinations treated different types of cancer cells.

The team tested the antitumor effects of 12 whole cannabis extracts on 12 human cancer cell lines in order to “determine whether whole cannabis preparations with specific phytocannabinoid profiles could be advantageous as therapy for certain cancer sub-types.” The findings were published in the journal Oncotarget.

“Our results show that specific cannabis extracts impaired the survival and proliferation of cancer cell lines as well as induced apoptosis.”

Each cell sample was treated with a marijuana extract in increasing doses (2-10 µg/ml) over the course of 24 hours. There were five preparations of cannabis that proved especially potent for a wide range of cancer types but, in general, the study shows there’s significant variability in effectiveness for different cancer types—even when the cancers originated in the same organ.

Via Oncotarget.

For example, two distinct forms of prostate cancer cells were found to be most sensitive to entirely different marijuana extracts.

The cannabis preparations also ranged widely in their effectiveness in preventing the proliferation of cancer cells. When applied to multiplying cells, there were three extracts that reduced the growths to 37-51 percent of their original size, compared to 68 percent for the control group. But there were other extracts that failed to reduce the spread in a statistically significant manner.

Some commonalities shared among the most potent cannabis extracts include a high concentration of THC and large amounts of phytocannabinoids in their decarboxylated form.

“Taken as a whole, we concluded that medical cannabis does not consist of a single therapeutic agent but rather a heterogeneous array of treatments,” the researchers wrote. “We propose that the fate of specific cancer cells following cannabis extract application is dependent upon the synergistic effects of its phytocannabinoid composition, concentration applied, along with the cell specific characteristics (e.g. cannabimimetic receptor expression).”

“This study demonstrates the anti-cancer activity of various whole cannabis extracts on a set of human cancer cell lines.”

The study concluded that “cannabis extracts were very potent in producing cell death and some of these extracts were of [THC]-rich type” and that, as previous studies have indicated, “using whole cannabis extracts is more effective in inducing cancer cell death than applying pure [THC] on the studied cells lines.”

“Furthermore, not all [THC]-rich extracts produce the same effects when applied at the same concentrations on a specific cancer cell line,” the study authors wrote. “These findings indicate that compounds other than [THC] in these extracts might act together in a polypharmacology way and determine the extract efficacy as antitumor agents.”

Interestingly, the researchers also theorized that the the “presence or absence of [cannabinoid receptors] in the tested cell lines may explain the differential potency of the extracts towards reducing cell survival.”

The team called for further research into the “specific properties and mechanisms of cancer cell insensitivity to cannabis extract effects.”

“We hope that this study will lay the groundwork for future preclinical studies and randomized controlled clinical trials in order to provide evidence for effective cannabis treatments for many cancer subtypes,” they concluded.

Recreational Marijuana Store Customers Consume To Help Pain And Sleep, Study Finds

Photo courtesy of Evan Johnson.

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Marijuana Legalization Associated With Decreased Interest In Alcohol, Study Finds

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Interest in alcohol declines after states legalize marijuana, according to a new study analyzing online behavior. But for reasons that aren’t entirely clear, interest in tobacco products increases following the policy change.

Another notable finding is that interest in cannabis among young people appears to decline after the end of prohibition.

Researchers from the University of Georgia and Syracuse University sought to identify the cross-commodity effects of legalization and used data from a “leading US-based web portal” from January 2014 to April 2017 to see how the implementation of adult-use legal marijuana programs in states changed online behavior such as web searches and engagement with advertisements.

The data set “covers over 28 million searches and 120 million ad impressions related to cannabis, alcohol and tobacco industries,” they wrote.

Published in the journal Marketing Science, the study reveals diverging trends for alcohol and tobacco.

Legalization “reduces search volume and advertising effectiveness for alcohol, but increases those for tobacco,” the authors wrote. “Hence, cannabis appears a substitute to alcohol, but not to tobacco.”

It also determined that recreational marijuana legalization leads to a nearly 17 percent increase in cannabis-related searches—however, that increase was “significantly attenuated” for young people, who did not search for marijuana more post-legalization. On the contrary, the study noted a “significant decrease in cannabis search[es] among the youth after” legalization.

“Contrary to widely held public concern after recreational cannabis is legalized, teenagers appear to lose interest, rather than gain interest,” study author Pengyuan Wang said in a press release. “Policymakers only concerned with an uptick in teen users, may want to rethink their stance.”

That finding is supported by another recent study exploring youth cannabis consumption. An analysis of federal data from 1993 to 2017 showed that self-reported past-month youth cannabis use decreased by about eight percent in states that legalized marijuana for adult use.

Alcohol searches decreased by about 11 percent after a state legalized marijuana, the researchers behind the new study found. They argued that the results show that the alcohol industry “has valid reasons to be concerned about legal cannabis and may need creative strategies to avoid market decline if [recreational cannabis legalization] passes.”

Via Marketing Science

However, predictions about marijuana’s potential to disrupt the tobacco industry might have been overblown, the study indicated. Searches for tobacco products increased by almost eight percent and so “tobacco companies may need to reexamine their presumption, and that anti-cannabis legalization is not in their best interest,” Wang said.

It’s not clear whether the analysis of tobacco search trends included cannabis-adjacent products such as blunts, rolling papers or vaporizer devices, which could overlap between tobacco and marijuana consumers. Marijuana Moment reached out to Wang for clarification but she did not immediately respond.

The research team said that their study is unique because it’s the first to analyze “large-scale unobtrusive behavioral data before and after policy change to unveil the treatment effect of [recreational cannabis legalization] using a difference-in-difference approach.”

“These findings on cross-commodity relationships help resolve the conflicting literature and provide distinct implications for practitioners,” the study authors wrote.

Youth Marijuana Use Declined In States That Legalized, Study Finds

Photo courtesy of Martin Alonso.

Marijuana Moment is made possible with support from readers. If you rely on our cannabis advocacy journalism to stay informed, please consider a monthly Patreon pledge.
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Legalizing Marijuana Leads To Fewer Illegal Grow Sites In National Forests, Study Finds

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In news that Smokey Bear, iconic protector of all forests, would be happy to hear, research shows that reports of illegal marijuana grow operations on federally protected lands fell after states began legalizing it for adult use.

“Arguably,” the study authors write, “our models hint that outright, national recreational cannabis legalization would be one means by which illegal growing on national forests could be made to disappear.”

“[W]e find that recreational cannabis legalization is associated with decreased reports of illegal grow operations on national forests.”

The research, which was published in the journal Ecological Economics earlier this month, is thought to be the first of its kind to analyze the effects of legalization policies on illegal outdoor grows in national forests throughout the United States. A separate recent study found that cannabis cultivation on federal lands specifically in the Pacific Northwest declined after legalization.

Researchers with the United States Department of Agriculture’s Forest Service used existing data on the number of illegal grow sites reported between 2004 and 2016 in 111 national forests. In addition to incorporating other variables into their analysis (including state marijuana policies, retail price for consumers, risk of exposure and others), they also came up with six simulated scenarios with policy changes to create random effects models of the number of reported grows.

For example, in one scenario, the study’s authors estimated how many illegal grow sites would exist if current laws legalizing both recreational and medical marijuana were revoked. In another simulation, wholesale and retail sales taxes on legal marijuana were eliminated in states that had already approved the sale and consumption of cannabis in 2016.

According to the study’s findings, “policies legalizing recreational cannabis production and consumption are associated with significantly lower numbers of reported illegal grows on national forests.”

The study’s predictive models showed that eliminating current state laws legalizing access to marijuana would result in “double-digit percentage increases in reported grows on national forests, while further expansion of the set of states with such laws passed by statewide referenda in 2016 (but only instituting applicable laws in 2017 or later, post-dating our dataset) would be expected to reduce growing on national forests by a fifth or more.”

If all 23 states that had approved medical marijuana by 2016 moved to more broadly legalize for adult use, the study continues, illegal cultivation sites in national forests would decline anywhere from 35 percent to 51 percent. However, it concluded that legalization of medical cannabis across the U.S. alone would not affect grow operations in national forests.

Mere decriminalization of possession was also found to have no significant effect on the number of illegal farms, though models did show that harsher penalties for illegal production and possession of marijuana, as well as stricter regulations on CBD oil and similar products, did. Meanwhile, an increase in law enforcement presence only made a slight difference (a 2.5 percent decrease in reported illegal grows) if local agencies increased their manpower by 20 percent.

Another issue, of course, is the role of taxes. If states reduced how much they tax legal sales by 6 to 13 percent, the number of illegal grows would decline. As researchers point out, “availability of legal cannabis does not encourage illegal cultivation unless the after-tax price for legal cannabis is substantially elevated relative to the illegal product.”

“As a practical matter,” the study authors summarize, “the number of cannabis grows on national forests could be reduced in two opposite ways: (1) legalization, or (2) increased efforts to deter, incarcerate, and otherwise discourage participation in the illegal market. Redefining what is legal perhaps would yield reductions that are cost less for the Forest Service, at least in the narrow sense of cannabis law enforcement demands, and would reduce the damages associated with cannabis cultivation.”

Ecologists have raised concerns about the environmental impact illegal marijuana cultivation sites have on national forests, such as the use of highly toxic rodenticide to ward off pests.

Illegal Marijuana Grows In Pacific Northwest Declined After Legalization, Study Finds

Photo by Aphiwat chuangchoem/Pexels.

Marijuana Moment is made possible with support from readers. If you rely on our cannabis advocacy journalism to stay informed, please consider a monthly Patreon pledge.
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